define off-target - EAS

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    off target
    [off target]
    DEFINITION
    1. so as to miss or fail to achieve the thing aimed at:
      "his shot was off-target" · "two off-target bombs"
      • not accurately described or predicted; incorrect:
        "the original estimate was off target"
    Translate off target to
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  2. People also ask
    What does off-target mean?
    What does off-target mean? Inaccurate, or inaccurately predicted. (prepositional phrase) The second quartile's figures were off target by 30%.
    yourdictionary
    What is the difference between on-target and off-target side effects?
    Off-target side effects are unexpected and are due to the effects from other targets or the structure of the drug. On-target side effects refer to the pharmacodynamic effect on normal tissues. Off-target side effects are unexpected and are due to the effects from other targets or the drug's structure.
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    What is off-target genome editing?
    Off-target genome editing refers to nonspecific and unintended genetic modifications that can arise through the use of engineered nuclease technologies such as: clustered, regularly interspaced, short palindromic repeats ( CRISPR )- Cas9, transcription activator-like effector nucleases ( TALEN ), meganucleases, and zinc finger nucleases (ZFN).
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    Can we use predicted cut sites to detect off-target events?
    Next-generation sequencing (NGS) data from a number of different techniques has shown that using predicted cut sites will not uncover rare off-target events. Following the initial discovery of CRISPR/Cas9 system, major adaptations were made to enable the system to work in human cells.
    ncbi.nlm.nih
  3. Off-target activity is biological activity of a drug that is different from and not at that of its intended biological target. It most commonly contributes to side effects.
    en.wikipedia.org/wiki/Off-target_activity
    en.wikipedia.org/wiki/Off-target_activity
  4. https://www.merriam-webster.com/dictionary/off target

    Webespecially : to set as a goal. 2. : to direct or use toward a target. Phrases. off target. : not valid : inaccurate. on target. : precisely correct or valid especially in interpreting or …

  5. https://www.thesaurus.com/browse/off-target

    Weboff-target as in off-center as in wide as in wide of the mark as in wrong synonyms for off-target Compare Synonyms askew adrift astray far-off inaccurate off the mark off-course …

  6. https://www.yourdictionary.com/off-target

    WebOff-target definition Filters Meanings Synonyms Away from a target. adjective 1 1 Away from a target. adverb 1 1 Inaccurate, or inaccurately predicted. The second quartile's …

  7. https://www.definitions.net/definition/off-target

    WebWiktionary (0.00 / 0 votes) Rate this definition: off-target adverb. Away from a target. off-target adjective. Away from a target.

  8. https://en.wikipedia.org/wiki/Off-target_genome_editing

    Off-target genome editing refers to nonspecific and unintended genetic modifications that can arise through the use of engineered nuclease technologies such as: clustered, regularly interspaced, short palindromic repeats (CRISPR)-Cas9, transcription activator-like effector nucleases (TALEN), meganucleases, and zinc finger nucleases (ZFN). These tools use different mechanisms to bind a predetermined sequence of DNA (“target”), which they cleave (or "cut"), cr…

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    • https://www.powerthesaurus.org/off-target

      WebOFF-TARGET in Thesaurus: 100+ Synonyms & Antonyms for OFF-TARGET.

    • On-Target and Off-Target Side Effects - Targeted Oncology

      https://www.targetedonc.com/view/on-target-and-off-target-side-effects

      WebSep 11, 2013 · Grace Dy, MD, Associate Professor, Department of Medicine, Roswell Park Cancer Institute, gives an overview of on-target and off-target side effects from anticancer …

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    • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8525399

      WebAug 17, 2021 · Together these studies suggested several important concepts: (1) the positions of mismatches affected off-target activity; the mismatches distal to PAM site …

    • https://www.merriam-webster.com/thesaurus/target

      Web1 as in victim a person or thing that is the object of abuse, criticism, or ridicule the hapless vice president quickly became the favorite target of late-night comedians Synonyms & …

    • https://www.cancer.gov/.../def/off-target-effect

      WebNCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine.



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