Sakoku (鎖国, "locked country") was the isolationist foreign policy of the Japanese Tokugawa shogunate under which, for a period of 265 years during the Edo period (from 1603 to 1868), relations and trade between Japan and other countries were severely limited, and nearly all foreign nationals were banned from entering Japan, while common Japanese people were kept …

Such reactions require strong base and high temperatures. 1,2-Disubstituted arenes serve as precursors to benzynes under milder conditions. Benzyne is generated by the dehalogenation of 1-bromo-2-fluorobenzene by magnesium. Anthranilic acid can be converted to 2-diazoniobenzene-1-carboxylate by diazotization and neutralization. Although explosive, this zwitterionic species is …