Poliovirus infects human cells by binding to an immunoglobulin-like receptor, CD155(also known as the poliovirus receptor or PVR) on the cell surface. Interaction of poliovirus and CD155 facilitates an irreversible

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Poliovirus is structurally similar to other human enteroviruses (coxsackieviruses, echoviruses, and rhinoviruses), which also use immunoglobulin-like molecules to recognize and enter host

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The primary determinant of infection for any virus is its ability to enter a cell and produce additional infectious particles. The presence of CD155 is thought to define the animals and

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Poliovirus uses two key mechanisms to evade the immune system. First, it is capable of surviving the highly acidicconditions of the stomach, allowing the virus to infect the host and

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Although humans are the only known natural hosts of poliovirus, monkeys can be experimentally infected and they have long been used to study poliovirus. In 1990–91, a small animal model of poliomyelitis was developed by two laboratories. Mice were

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In 1981, Racaniello and Baltimore used recombinant DNA technology to generate the first infectious cloneof an animal RNA virus, poliovirus. DNA encoding the RNA genome of poliovirus was

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A modification of the poliovirus, called PVSRIPO, was tested in early clinical trials as a possible treatment for cancer.

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