The province of Isernia (Italian: provincia di Isernia) is a province in the region of Molise in Italy. The provincial capital is the city Isernia and the president of the province is Alfredo Ricci. The province of Isernia has an area of 1,535. 24 square kilometres (592. 76 sq mi) and a population of 86,405 inhabitants as of 2016.

Geography. The province of Isernia is a largely mountainous area of central Italy, part of the region of Molise. To the southwest the mountains decrease in height and the wooded hills give way to the plains around Venafro. To the northeast is the Province of Campobasso, also part of Molise, and to the north the Provinces of L'Aquila and Chieti,...

Isernia ( Italian pronunciation: [iˈzɛrnja] ( listen)) is a town and comune in the southern Italian region of Molise, and the capital of province of Isernia .

Isernia was destroyed by the Saracens in 800, sacked by Markward of Anweiler, Count of Molise, in 1199, and set on fire in 1223 by the soldiers of Frederick II. In 1519 it was freed from feudal servitude by Charles V, Holy Roman Emperor and became a city in the Kingdom of Naples . Earthquakes in 847, 1349, 1456 and 1805 caused massive destruction.