Discovery. Interferon-alpha, an interferon type I, was identified in 1957 as a protein that interfered with viral replication. The activity of interferon-gamma (the sole member of the interferon type II class) was described in 1965; this was the first identified lymphocyte-derived mediator. Macrophage migration inhibitory factor (MIF) was identified simultaneously in 1966 by John …

stratum spinosum; stratum granulosum; stratum lucidum; stratum corneum; Les kératinocytes passent progressivement de la couche basale vers les couches supérieures par différenciation cellulaire jusqu'au stratum corneum où ils forment une couche de cellules mortes nommées squames, par mort cellulaire (différente de l'apoptose). Cette ...