WebSan Francisco (/ ˌ s æ n f r ə n ˈ s ɪ s k oʊ /; Spanish for "Saint Francis"), officially the City and County of San Francisco, is the commercial, financial, and cultural center of Northern California.The city proper is the fourth most populous in California and 17th most populous in the United States, with 815,201 residents as of 2021. It covers a land area of 46.9 square …