cystatin b - EAS
- CSTB cystatin B [ (human)]-The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1). One type of mutation responsible for EPM1 is the expansion in the promoter region of this gene of a CCCCGCCCCGCG repeat from 2-3 copies to 30-78 copies. [provided by RefSeq, Jul 2016]-Other designations: cystatin-B · cystatin B (stefin B) · epididymis secretory sperm binding protein · liver thiol proteinase inhibitor-https://www.ncbi.nlm.nih.gov/gene/1476
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See all on Wikipediahttps://en.wikipedia.org/wiki/Cystatin_BCystatin-B is a protein that in humans is encoded by the CSTB gene. The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three … See more
Cystatin B has been shown to interact with Cathepsin B. See more
• GeneReviews/NCBI/NIH/UW entry on Unverricht-Lundborg Disease or EPM1
• The MEROPS online database for peptidases and their inhibitors: I25.003 See more• Turk V, Bode W (1991). "The cystatins: protein inhibitors of cysteine proteinases". FEBS Lett. 285 (2): 213–9. doi:10.1016/0014-5793(91)80804-C. PMID 1855589 See more
Wikipedia text under CC-BY-SA license- https://www.sciencedirect.com/.../cystatin-b
WebCystatin B-Deficient Mice – A Model for EPM1. The Cystatin B-deficient mice with targeted disruption of the mouse Cstb gene mimic the human phenotype …
- https://www.sciencedirect.com/topics/medicine-and-dentistry/cystatin-b
WebThe Cystatin B-deficient mice with targeted disruption of the mouse Cstb gene mimic the human phenotype reasonably well. The mice develop myoclonic seizures during sleep by …
- https://www.ncbi.nlm.nih.gov/gene/1476
Webcystatin B expression was significantly and inversely correlated with lung tumor stage and tumor grade; The results demonstrate that cystatin B interferes with the STAT-1 …
- https://pubmed.ncbi.nlm.nih.gov/19342095
WebCystatin (CSTB, also known as stefin B), a cysteine protease inhibitor, recently was found to be down-regulated in the proteome of uninfected and HIV-1-infected placental …
- Author: Claribel Luciano-Montalvo, Loyda M. Meléndez
- Publish Year: 2009
- https://pubmed.ncbi.nlm.nih.gov/16321512
WebCystatin B, an intracellular cysteine proteinase inhibitor, exhibits a lysosomal distribution preferentially in osteoclasts but it's role in osteoclast physiology has remained unknown. …
- https://en.wikipedia.org/wiki/The_Dalles,_Oregon
Web41-72950. Website. City of The Dalles. The Dalles / ˈdælz / is the largest city of Wasco County, Oregon, United States. The population was 16,010 at the 2020 census, and it is …
- https://medlineplus.gov/genetics/gene/cstb
WebThe CSTB gene provides instructions for making a protein called cystatin B. This protein reduces the activity of (inhibits) enzymes called cathepsins. Cathepsins help break …
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5693439
WebNov 17, 2017 · Cystatin B, cathepsin D and cathepsin L were analyzed by the Proximity Extension Assay technique using the Proseek Multiplex CVD 96x96 reagents kit (Olink …
Cystatin B Products: R&D Systems
https://www.rndsystems.com/target/cystatin-bWebCystatin B, also known as Stefin B or liver thiol proteinase inhibitor, is a member of family 1 of the cystatin superfamily. It is a 98 amino acid, intracellular inhibitor regulating the …
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