dapk3 - EAS

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  1. See more
    See all on Wikipedia
    https://en.wikipedia.org/wiki/DAPK3

    Death-associated protein kinase 3 is an enzyme that in humans is encoded by the DAPK3 gene. Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of … See more

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  2. DAPK3 Gene - GeneCards | DAPK3 Protein | DAPK3 Antibody

    https://www.genecards.org/cgi-bin/carddisp.pl?gene=DAPK3

    273 rows · Nov 09, 2022 · DAPK3 (Death Associated Protein Kinase 3) is a Protein Coding …

    • SYMBOLEXTERNAL ID(S)DETAILS
      CDK3ENSP00000400088 ...STRING: ENSP00000400088 ...
      DAPK3O43293EBI-77293, EBI-77293 ...
      NLKQ9UBE8 ...EBI-77293, EBI-366978 ...
      PPP1R12AO14974 ...EBI-77293, EBI-351726 ...
      See all 273 rows on www.genecards.org
    What is the role of DAPK3 in apoptosis?
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  3. People also ask
    What does DAPK3 stand for?
    Death-associated protein kinase 3 is an enzyme that in humans is encoded by the DAPK3 gene. Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells.
    en.wikipedia.org/wiki/DAPK3
    How does death-associated protein kinase 3 (DAPK3) inhibit gastric cancer progression?
    DAPK3 inhibits gastric cancer progression via activation of ULK1-dependent autophagy Dysregulation of the balance between cell proliferation and cell death is a central feature of malignances. Death-associated protein kinase 3 (DAPK3) regulates programmed cell death including apoptosis and autophagy.
    Is DAPK3 a murine gene?
    Unlike most other mammalian genes, murine (rat and mouse) DAPK3 has undergone accelerated evolution and diverged from the tightly conserved consensus that is maintained from fish to human. DAPK3 has been shown to interact with PAWR and Death associated protein 6.
    en.wikipedia.org/wiki/DAPK3
    Is DAPK3 a critical activating kinase for Sting?
    Here we show that DAPK3 is a critical activating kinase for STING via two distinct processes: (1) maintaining steady-state STING protein levels by attenuating STING K48-linked poly-ubiquitination; and (2) promoting agonist-induced STING K63-linked poly-ubiquitination via direct phosphorylation of E3 ubiquitin ligases.
    www.nature.com/articles/s41590-021-00896-3
  4. https://www.ncbi.nlm.nih.gov/gene/1613

    Oct 26, 2022 · DAPK3 controls proliferation, migration and tumor growth through activation of ERK/c-Myc signaling in lung adenocarcinoma cells. The results revealed mutations caused a …

  5. https://pubmed.ncbi.nlm.nih.gov/33037394

    The coordinate expression of DAPK3 with ULK1 Ser556 phosphorylation was confirmed in clinical GC samples, and this co-expression was correlated with favorable survival outcomes in …

    • Author: Guan-Man Li, Lei Li, Meng-Qing Li, Xu Chen, Qiao Su, Zhi-Juan Deng, Hai-Bo Liu, Bin Li, Wen-Hui Zhan...
    • Publish Year: 2021
  6. https://pharos.nih.gov/targets/DAPK3

    Involved in regulation of cell cycle progression and cell proliferation. May be a tumor suppressor. Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis …

  7. https://www.cellsignal.com/products/primary...

    Overexpression of DAPK3/ZIPK, but not a catalytically inactive mutant, can induce apoptosis (7). DAPK3 was also identified as a myosin light chain kinase, demonstrating ability to phosphorylate the regulatory light chain of myosin II in …

  8. https://pubmed.ncbi.nlm.nih.gov/31811899

    Dec 09, 2019 · Death-associated protein kinase-3 (DAPK3) regulates a variety of cellular functions; however, the relationship between DAPK3 and autophagy is unknown. In this study, …

  9. https://www.nature.com/articles/s41590-021-00896-3

    Mar 25, 2021 · DAPK3 is a positive regulator of STING signaling. To examine tumor-intrinsic regulation of STING, we performed genetic loss-of-function screening of 1,001 human tumor …

  10. https://www.thermofisher.com/order/catalog/product/PR7001B

    DAPK3 is a serine⁄threonine kinase which is functionally linked to cell motility, smooth muscle contractility and cell death processes. For Research Use Only. Not for use in diagnostic …

  11. https://www.thermofisher.com/order/catalog/product/PV3686

    DAPK3 is a serine⁄threonine kinase which is functionally linked to cell motility, smooth muscle contractility and cell death processes. For Research Use Only. Not for use in diagnostic …



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