off target effects - EAS

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    Off-target effects cause a severe type of problem in the organism at the genomic level, large deletions and genomic rearrangements, which rarely could occur as a consequence of dsDNA breaks [ 13 ].
    Author: Muhammad Naeem, Saman Majeed, Mubasher Zahir Hoque, Irshad Ahmad
    Publish Year: 2020
    DOI: 10.3390/cells9071608
    Publication: Cells. 2020 Jul; 9(7): 1608.

    Latest Developed Strategies to Minimize the Off-Target Effects in …

    www.ncbi.nlm.nih.gov/pmc/articles/PMC7407193/
    www.ncbi.nlm.nih.gov/pmc/articles/PMC7407193/
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  2. 大家還會問
    What are off-target side effects?
    Off-target side effects are unexpected and are due to the effects from other targets or the structure of the drug.

    On-Target and Off-Target Side Effects

    www.targetedonc.com/view/on-target-and-off-target-side …
    搜尋: What are off-target side effects?
    What is off target activity of a drug?
    Off-target activity. Off-target activity is biological activity of a drug that is different from and not at that of its intended biological target. It most commonly contributes to side effects. However, in some cases, off-target activity can be taken advantage of for therapeutic purposes.

    Off-target activity - Wikipedia

    en.wikipedia.org/wiki/Off-target_activity
    搜尋: What is off target activity of a drug?
    What are the latest approaches to reduce off-target effects?
    Numerous types of approaches have been developed to reduce off-target effects. Here, we review several latest approaches to reduce the off-target effects, including biased or unbiased off-target detection, cytosine or adenine base editors, prime editing, dCas9, Cas9 paired nickase, ribonucleoprotein (RNP) delivery and truncated gRNAs.

    Latest Developed Strategies to Minimize the Off-Target

    www.ncbi.nlm.nih.gov/pmc/articles/PMC7407193/
    搜尋: What are the latest approaches to reduce off-target effects?
    What is off-target activity?
    Off-target activity is biological activity of a drug that is different from and not at that of its intended biological target. It most commonly contributes to side effects. However, in some cases, off-target activity can be taken advantage of for therapeutic purposes.

    Off-target activity - Wikipedia

    en.wikipedia.org/wiki/Off-target_activity
    搜尋: What is off-target activity?
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  3. Off-target Effects in CRISPR/Cas9-mediated Genome Engineering

    https://pubmed.ncbi.nlm.nih.gov/26575098

    網頁2015/11/17 · However, the high frequency of off-target activity (≥50%)-RGEN (RNA-guided endonuclease)-induced mutations at sites other than the intended on-target site-is one major concern, especially for therapeutic and clinical applications.

    • 作者: Xiao-Hui Zhang, Xiao-Hui Zhang, Louis Y Tee, Xiao-Gang Wang, Qun-Shan Huang, Shi-Hua Yang
    • Publish Year: 2015

  4. Off-target Effects in CRISPR/Cas9-mediated Genome …

    https://www.sciencedirect.com/science/article/pii/S216225311630049X

    網頁2015/1/1 · off-target effects might be cell-type-specific and highly depending on the integrity of double-stranded breaks (dsbs) repair pathways of particular cell type. 22 for example, …

    • 作者: Xiao-Hui Zhang, Xiao-Hui Zhang, Louis Y Tee, Xiao-Gang Wang, Qun-Shan Huang, Shi-Hua Yang
    • Publish Year: 2015

  6. Off-target effects and the solution - PubMed

    https://pubmed.ncbi.nlm.nih.gov/30962524

    網頁Off-target effects and the solution Nat Plants. 2019 Apr;5(4):341-342. doi: 10.1038/s41477-019-0406-z. Authors Jintao Tang 1 2 3 , Letian Chen 1 2 3 , Yao-Guang Liu 4 6 Affiliations …

    • 作者: Jintao Tang, Letian Chen, Yao-Guang Liu
    • Publish Year: 2019

  7. RNAi实验中脱靶效应(Off-Target Effect)_百度文库

    https://wenku.baidu.com/view/f948f4f3ba0d4a7302763aae.html

    網頁Off-garget effects (脱靶效应)最早是 Dharmacon 科学家的 Jackson 和他的同事们提出（Fedorov, Y., et al. "Off-targeting By siRNA Can Induce Toxic Phenotype." RNA …

  8. On-Target and Off-Target Side Effects

    https://www.targetedonc.com/view/on-target-and-off-target-side-effects

    網頁2013/9/11 · Common on-target side effects include skin rash from inhibitors of the MAP kinase pathway or ocular toxicities from MEK inhibitors, Hsp90 inhibitors, and selective …

  9. Off-target effect - Innovative Genomics Institute (IGI)

    https://innovativegenomics.org/glossary/off-target-effect

    網頁Off-target effect. When a genome engineering enzyme cuts DNA at an unintended, ”off-target,” site that is similar to the intended target.

  10. 基因編輯「脫靶效應」的隱憂，仍待育種家尋求解方

    https://www.agritech.org.tw/2018/05/blog-post_24.html

    網頁2018/5/24 · 此外關於CRISPR技術的脫靶效應（off-target effect）也是科學家無法百分之百確認的問題。 「脫靶」指的是：基因編輯的時候，CRISPR-Cas9系統沒有在正確的目標基 …

  11. Latest Developed Strategies to Minimize the Off-Target …

    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7407193

    網頁2020/7/2 · Off-target effects could lead to lethal genetic mutations that cause loss of gene function, ultimately cancer cells in animals and undesirable phenotype (disease …

  12. Off-target genome editing - Wikipedia

    https://en.wikipedia.org/wiki/Off-target_genome_editing

    網頁Currently, off-target effects of CRISPRi are minimal, and show a reduced response and sensitivity to single-base mismatches. [44] Importantly, when non-specific effects do …

  13. Off-target activity - Wikipedia

    https://en.wikipedia.org/wiki/Off-target_activity

    網頁It most commonly contributes to side effects. However, in some cases, off-target activity can be taken advantage of for therapeutic purposes. An example of this is the repurposing of …



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