US Organization, a Black nationalist group in the United States founded in 1965; United Services Club or US Club, a golf club in Mumbai; United Society, an Anglican charitable organization first founded in 1701; United Synagogue, the union of British Orthodox synagogues founded in 1870;

Film and television. The Two of Us, a French film directed by Claude Berri; The Two of Us, a South African film directed by Ernest Nkosi; Two of Us, a gay-themed British television film; Two of Us, an American television drama about a fictionalized meeting between Paul McCartney and John Lennon; The Two of Us (1981 TV series), a sitcom starring Peter Cook and Mimi Kennedy

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