on target off tumor - EAS
- In many cases, on-target/off-tumor effects can also be evaluated by loading the target antigen onto cell types that would not normally express the tumor-associated antigen. This platform is also suitable for testing the ability of immunomodulators to enhance the killing of tumor cells by endogenous immune cells.
www.criver.com/products-services/discovery-services/pharmacology-studies/on… - People also ask
- https://pubmed.ncbi.nlm.nih.gov/28341563
May 03, 2017 · Abstract. Chimeric antigen receptors (CARs) combine T cell activation with antibody-mediated tumor antigen specificity, bypassing the need for T cell receptor (TCR) ligation. A limitation of CAR technology is on-target off-tumor toxicity caused by target antigen …
- Author: Jonathan Fisher, Pierre Abramowski, Nisansala Dilrukshi Wisidagamage Don, Barry Flutter, Anna Capsom...
- Publish Year: 2017
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- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5417796
May 03, 2017 · On-target off-tumor toxicity is one of the major impediments to successful cancer immunotherapy. It is typically approached in two ways: either by avoiding antigens, which may …
- Author: Jonathan Fisher, Pierre Abramowski, Nisansala Dilrukshi Wisidagamage Don, Barry Flutter, Anna Capsom...
- DOI: 10.1016/j.ymthe.2017.03.002
- Publish Year: 2017
- Publication: Mol Ther. 2017 May 3; 25(5): 1234-1247.
- https://pubmed.ncbi.nlm.nih.gov/28506593
Aug 02, 2017 · T cells carrying these CD38-CARs were extensively evaluated for their on-tumor/off-tumor cytotoxicity as well as CD38-dependent proliferation and cytokine production. …
- Author: Esther Drent, Maria Themeli, Renée Poels, Regina de Jong-Korlaar, Huipin Yuan, Joost de Bruijn, Anto...
- Publish Year: 2017
On-Target and Off-Target Side Effects - Targeted Oncology
https://www.targetedonc.com/view/on-target-and-off-target-side-effectsSep 11, 2013 · On-target side effects refer to the pharmacodynamic effect on normal tissues that occurs when the target that's being inhibited in the tumor is also being inhibited in the normal …
- https://www.nature.com/articles/s41571-022-00704-3
Nov 23, 2022 · Zhang, W. et al. Abstract PO074: Logic-gating HER2 CAR-T to the tumor microenvironment mitigates on-target, off-tumor toxicity without compromising cytotoxicity …
- https://pubmed.ncbi.nlm.nih.gov/32544101
Jul 23, 2020 · Off-tumor targeting of human antigens is difficult to predict in preclinical animal studies and can lead to serious adverse effects in patients. To address this, we developed a …
- https://www.sciencedirect.com/science/article/pii/S1525001617302101
Aug 02, 2017 · A Rational Strategy for Reducing On-Target Off-Tumor Effects of CD38-Chimeric Antigen Receptors by Affinity Optimization Introduction. Cytotoxic T cells endowed with …
- https://pubmed.ncbi.nlm.nih.gov/33239386
Nov 25, 2020 · This clinical activity was achieved without on-target off-tumor toxicity. Targeting neuroblastoma with GD2 CAR-T cells appears to be a valid and safe strategy but requires …
- https://www.science.org/doi/10.1126/scitranslmed.abd6169
The treatment was well tolerated without on-target off-tumor toxicity but did not achieve objective clinical responses. Abstract The reprogramming of a patient’s immune system …
- https://www.fdli.org/2020/12/regulations-of-car-t...
On-target off-tumor detection, tumor lysis syndrome, and cytopenia are other adverse effects of CAR T-cell therapy. [27] Risk Evaluation and Mitigation Strategies (REMS), as mandated by …
