The structure of full-length GSDMD consists of two domains, the 31 kDa N-terminal (GSDMD-N) and 22 kDa C-terminal (GSDMD-C) domains, separated by a linker region.GSDMD-C can be divided into four subdomains and is composed of 10 α-helices and two β-strands, forming a compact globular fold.The linker helix contacts the two helix-repeats which consist of four-helix bundles.

660s BC. 669 BC: Assurbanipal succeeds his father Esarhaddon as king of Assyria. 669 BC: Argos defeats Sparta for the last time, this time using a hoplite phalanx, at the battle of Hysiae. 668 BC: Shamash-shum-ukin, son of Esarhaddon, becomes King of …