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S phase (Synthesis Phase) is the phase of the cell cycle in which DNA is replicated, occurring between G1 phase and G2 phase. Since accurate duplication of the genome is critical to successful cell division, the processes that occur during S-phase are tightly regulated and widely conserved. See more
Entry into S-phase is controlled by the G1 restriction point (R), which commits cells to the remainder of the cell-cycle if there is adequate nutrients and growth signaling. This transition is essentially irreversible; after passing the … See more
Throughout M phase and G1 phase, cells assemble inactive pre-replication complexes (pre-RC) on replication origins distributed throughout the genome. During S-phase, the cell converts pre-RCs into active replication forks to initiate DNA replication. This … See more
Immediately after division, each daughter chromatid only possesses half the epigenetic modifications present in the paternal chromatid. The cell must use this partial set of … See more
• S phase index (SPI)
• S-fraction or S-phase fraction (oncology/pathology prognosis)
• Restriction point See moreSince new DNA must be packaged into nucleosomes to function properly, synthesis of canonical (non-variant) histone proteins … See more
Free histones produced by the cell during S-phase are rapidly incorporated into new nucleosomes. This process is closely tied to the replication fork, occurring immediately in … See more
During S-phase, the cell continuously scrutinizes its genome for abnormalities. Detection of DNA damage induces activation of three canonical S-phase "checkpoint … See more
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