conservative IDR peaks: Peaks derived from IDR analysis of biological replicates. IDR, or Irreproducible Discovery Rate, measures the reproducibility of the assay in question. The optimal set of peaks is more sensitive, especially when one replicate has substantially lower data quality than the other. bed and bigBed (narrowPeak) optimal IDR peaks

These peaks are thresholded to sample enough noise in the experiment for efficient statistical comparison of replicates in subsequent steps; as such, many false positives are expected to be present. They are not meant to be interpreted as definitive binding events, but are rather intended to be used as input for subsequent statistical comparison of replicates.